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This combination should only be used under medical supervision with regular lab monitoring

A Phase I/II trial (NCT05130437) for this indication has been initiated in pediatric patients to evaluate the long-term safety of mRNA-3927

Quick Take (TLDR) Mostly animal and in vitro data plus multiple very small uncontrolled human reports (knee pain case series n=16, interstitial cystitis pilot n=12, 2subject IV infusion) and no randomized controlled trials or published human pharmacokinetic profiles

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