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36 Tumor cell state plasticity drives therapeutic relapse by surviving cytotoxic insults and reshaping the TME to suppress effector immune responses
The National Heart, Lung and Blood Institute Heart Failure Clinical Research Network designed the Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT) study (NCT01800968) to test the hypothesis that liraglutide would improve myocardium bioenergetics leading to post-hospitalization clinical stability in subjects with advanced HF and reduced left ventricular ejection fraction, with and without diabetes [47]
Regulation of cell proliferation and apoptosis: Glutathione depletion is a signal for apoptosis (programmed cell death), while adequate levels support normal cell proliferation [2][5]
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