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[9] Diastolic reductions were proportionally smaller, around 8 mmHg, consistent with a vasodilatory mechanism acting on resistance arteries rather than a cardiac-output effect
The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48
Cardiovascular Diabetology
Crediting the combinations performance to cagrilintide alone overstates the monotherapy evidence
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