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Any deviation from licensed dosing regimens should only occur under close medical supervision, as the risk-benefit profile at sub-therapeutic doses remains poorly characterised
Dosing must only follow the protocol of the specific authorised trial in which a participant is enrolled
It has been pointed out in the literature (31, 32) that RRM2 is involved in DNA synthesis and repair, and its high expression is often closely associated with cell cycle acceleration and high proliferation of tumor cells
doi: 10.1016/j.bbadis.2013.01.008 50 DumanR
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