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From a research-design standpoint, timing matters because GH secretion is pulsatile and influenced by food intake, sleep cycles, glucose, and endogenous somatostatin signaling
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some of the study period preceded the approval of semaglutide and tirzepatide to treat obesity
By targeting these pathways together, early research suggests retatrutide may offer enhanced benefits for weight loss and blood sugar control compared to existing single- or dual-agonist medications
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