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In addition, potency of MEDI4166 for human GLP-1R in transfected CHO cells displayed a 45-fold reduction compared to the GLP-1-Fc(4) control molecule in the cAMP accumulation assay (Supplementary Table 8)

\n\n\n\n Importantly, BPC-157 has not been found to significantly raise or lower blood pressure in healthy animal models, and it does not appear to disrupt hormonal axes in ways that would suggest meaningful endocrine system interference

doi: 10.1074/jbc.272.7.4108 85 KoltermanOGKimDDShenLRugglesJANielsenLLFinemanMSet al