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A clinical relevance for CV disease is suggested, for example, for IL-1RN, MMP-3, CD163, and IL-6 and its receptor (30)
All these trials were designed to evaluate the primary outcome of 3-MACE defined as cardiovascular death, nonfatal myocardial infarct, and nonfatal stroke, except for the ELIXA trial of exenatide ER, which included hospitalization for unstable angina as an additional component of the 4-MACE composite outcomes
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Human data are limited
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