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When an agonist binds, it can activate multiple downstream signaling cascades, most importantly the cAMP cascade and the -arrestin cascade, and the relative strength of each cascade is a function of how the agonist sits in the receptor pocket
A retrospective study
(PubMed) Borrelli F, Capasso R, Izzo AA
Conversely, for women with polycystic ovary syndrome (PCOS) or obesity-related menstrual irregularities, weight loss can actually restore ovulatory cycles and improve period regularity
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