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At week 72, for the efficacy estimand, tirzepatide MTD had greater reductions in percentage weight versus semaglutide MTD (mean [95% confidence interval (CI)] 6.2% [ 7.8, 4.6]) and waist circumference ( 5.4% [ 7.1, 3.7])

Moreover, many aspects of this trial are designed with event rates in mind, and the lack of per-protocol analysis threatens the validity of these findings

The criteria matter

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