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Participants lost an average of nearly 29% of their starting body weight (about 71 lbs) after using retatrutide 12 mg for 68 weeks (about 15.5 months)
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For mild to moderate joint discomfort without red flag features, management should be guided by NICE NG226 (Osteoarthritis in over 16s: diagnosis and management) and may include: Exercise and physiotherapy , which are central to NICE-recommended management
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