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Recent evidence also demonstrates the dual role of nicotine, which primarily promotes hepatocarcinogenesis through activation of multiple oncogenic signaling cascades, including 7-nicotinic acetylcholine receptor (7-nAChR)/JAK2/STAT3, CYP1A1/PI3K/Akt signaling mediated by NF-B and AP-1, SETDB1/CDK6-mediated STAT1 stabilization, GCF2-driven Wnt/-catenin/SOX2 signaling, and the 2-adrenergic receptor (2-AR)/PI3K/Akt pathway [35,36,37]
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Funding The research was supported by the Ministry of Science and Technology (Taiwan) (108-2314-B-002-032, 106-2314-B-002 -039 -MY3 and 108-2321-B-002 -035, 106-2319-B-492-001, 109-2327-B-002 -005, 109-2314-B-002 -103 -MY3, 109-2314-B-002 -064 -MY3), Program for Translational Innovation of Biopharmaceutical Development-Technology Supporting Platform Axis (AS-KPQ-106-TSPA) and Russian Science Foundation (Grant # 19-15-00010)
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