Conclusions and Future Perspectives Overall, GLP-1RAs are considered novel blood glucose lowering drugs used in the treatment of T2MD (229), owing to their advantages of lowering blood pressure, lowering the levels of fasting blood glucose, lowering HbA1c, inducing weight loss, and being associated with a low incidence of hypoglycemia
Chow vehicle (grey triangles) for 24 weeks ( n = 9), MASH vehicle and semaglutide 123 g/kg for 8 weeks ( n = 16 [black triangles] and n = 16 [light blue circles], respectively), 16 weeks ( n = 16 [black triangles] and n = 16 [blue rectangles]), and 24 weeks ( n = 15 [black triangles] and n = 15 [dark blue square])
In mice, these drugs increase the risk of thyroid cancer but the drugs dont show the same pattern in humans, and might actually be protective
Speaking of cost, Semaglutide can be a bit more costly than some other weight loss medications