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These data provide an explanation for CNS activation even though monoclonal antibodies have minimal brain penetrance, reaching concentrations of around 0.10.4% of the monoclonal antibody concentrations in the plasma 50,51
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Monitor renal function in patients reporting adverse reactions that could lead to volume depletion, especially during dosage initiation and escalation. Source: Ozempic prescribing information, Section 5.6 (Acute Kidney Injury Due to Volume Depletion), via DailyMed (NLM), label revised May 2026
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