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Other contributors Smoking/vaping (can mask bleeding but worsens disease) Diabetes and poor blood sugar control Dry mouth, stress, and some medications Pregnancy/hormonal changes (more gum sensitivity) Safe self-care now what helps most (and what to avoid) What helps most Brush gently twice daily with a soft brush, aiming along the gumline

COX-1 and COX-2 Inhibition COX-1 Inhibition: This impacts protective prostaglandins that maintain the stomach lining and support kidney function and platelet aggregation (blood clotting)

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Trial registration ClinicalTrials.govNCT04263415