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Long-term metformin use is a recognised cause of low B12: the MHRA now lists it as a common side effect, affecting up to one in ten users
The concern exists because some peptides promote angiogenesis, the same process tumours exploit
In the pancreas, GLP-1 stimulates the release of insulin, increases the amount of insulin-producing pancreatic cells (beta cells) and reduces the release of glucagon a hormone that raises blood sugar levels
PubMed Central, Kolodny, Tamar, et al
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