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This observation holds implications for the design and therapeutic use of positive GLP-1R allosteric modulators

Common signs include: Persistent fatigue and weakness Pale or slightly jaundiced skin Shortness of breath and dizziness Tingling or numbness in the hands and feet Mouth ulcers or a sore, red tongue (glossitis) Cognitive difficulties, including memory problems or low mood Hair thinning or increased hair shedding (a possible, non-specific manifestation not a hallmark symptom) In the UK, certain groups are at higher risk and should be particularly vigilant