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Common : Nausea (up to 44%), vomiting, diarrhea, constipation Less common : Fatigue, dyspepsia, bloating, dizziness Rare : Cholelithiasis, acute pancreatitis Serious : Risk of thyroid tumors (animal data), kidney impairment due to dehydration Proper storage is critical to maintaining the products efficacy
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It requires daily injections because its half-life is only 13 hours, reaching steady state within two to three days
As with all GLP-1 agonists, long-term post-marketing surveillance will be essential to characterize the pancreatic safety profile with greater statistical precision, particularly for rare events such as acute pancreatitis (estimated background rate of approximately 35 per 100,000 person-years in the general population) and the theoretical concern about pancreatic cancer
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