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In addition, VLCDs may not be nutritionally complete and provide far fewer calories than most people need to maintain a healthy weight
PMID: 29983246
A 2025 network meta-analysis (PMC12544991) found retatrutide produced 16.34 kg absolute weight loss versus placebo, compared with 11.82 kg for tirzepatide
Where there is somewhat more signal, it is for oral or topical forms in small controlled studies (a randomized, placebo-controlled study of oral glutathione as a whitening agent)
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