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Several studies suggest that inflammation may contribute to depression by affecting the function of neuronal mitochondria in the brain [20]
GCGR/GLP-1R agonist: OR: 0.23, 95%CI: 0.070.75, P = 0.02
The higher GI event rates with aleniglipron (65% nausea) versus orforglipron's profile are a concern, though dose optimization may improve tolerability
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