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2 Additionally, new indications for major adverse cardiovascular events (MACE) risk reduction are anticipated, which will likely broaden the population eligible for these medications under clinical guidelines

In the present study, we carried forward these four ACs and tested whether the relationships with depression predicted from genomic data (negative with C2 and C3, and positive with C8 and C10) were expressed in actual phenotypes measured in a large cohort (N ~ 2500) with extensive clinical phenotyping

Their functional plasticity, shifting between inflammatory, repair, or anti-inflammatory states, depends on metabolic adaptation and lipid remodeling, including choline uptake and phospholipid reorganization ( 2.1.1 Macrophages and dendritic cells Macrophage functions, such as cytokine and chemokine secretion, phagocytosis, and organelle biogenesis, are intricately linked to membrane phospholipid composition, curvature, and charge ( Figure 3 )

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