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At the same time, liver inflammation, intestinal flora displacement and concurrent infection caused by cirrhosis lead to the release of a large number of inflammatory factors and endotoxemia, causing renal microcirculation dysfunction, which can induce renal function injury (Rad et al., 2024)

To improve the local resolution of CTR-RAMP extracellular domains (ECDs), focused refinements (masking around receptors or ECD domains) were performed

Gastrointestinal side effects such as nausea, abdominal discomfort and/or diarrhea should be monitored closely

To understand the effects of estradiol on such a complicated network, mathematical computation is required