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The FDA-approved labeling for semaglutide, liraglutide, tirzepatide, and other GLP-1 medications does not list cortisol reduction as a mechanism of action or therapeutic effect

As described in the same source, This is why the body needs to metabolise your muscles when youre in a calorie deficit. Early in a calorie deficit, the body first uses glycogen stores for energy

Overeating further disrupts the gut bacteria that help make GLP-1

It has been reported that the intestinal environment (bacteria and viruses) changes even before the onset of type 1 diabetes mellitus (T1DM) and that there are bacteria that inhibit the onset of T1DM 3,4,5