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The impact on weight accumulates while the drug is titrated to a maintenance dose, occurring every four weeks in these studies
No pharmaceutical company has funded the human clinical trials required for FDA approval
A phase II study result showed that administering a high dose of survodutide, up to 1.8 mg twice weekly, resulted in over 50% of T2D participants achieving more than 5% body weight reduction, and over 25% experiencing a weight loss exceeding 10% [111]
The heart rate increase of 4 to 7 beats per minute is within acceptable range but requires monitoring (Coskun et al., Nature 2022)
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