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doi: 10.14715/cmb/2023.69.3.25 8 ChenLLiXLiuLYuBXueYLiuY
The hydrophobic residues involve in fluoxetine binding are L298, P303, L330, A334, A338, A542, M546, A1160, V1163, and L1192
The problem was the side effects associated, particularly with GLP-1, are what we call peak to trough: so the difference between the highest amount of drug and the lowest and then going back up again to the highest caused by this twice-a-day dosingwhich you can imagine someone bouncing around maybe two to three times, the drug at peak, then trough, causes a lot of GI distress
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