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Common causes of poor dissolution: Peptide has a high proportion of hydrophobic amino acid residues (leucine, isoleucine, valine, phenylalanine) Target concentration is too high relative to the peptides aqueous solubility limit Solvent temperature is below room temperature, reducing dissolving capacity Insufficient wait time before manual intervention Peptide has undergone partial aggregation during storage Solvent alternatives and when to use them: If a peptide does not dissolve within 5 minutes in bacteriostatic water, switch to a mild acetic acid solution or introduce a small initial volume of DMSO before completing the dilution with aqueous solvent
Source: Cedars-sinai The presented results ( Source ) indicated that of the study participants, 37 people were on liraglutide and 18 on the placebo treatment
2015;149(2):367-78.e5 (quiz e14-5)
NO significativamente
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