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The alterations in the MPTP lead to swelling, osmotic water influx, and release of pro-apoptotic factors, which can lead to cell death [85]
Selected recent literature for research reference: Coutinho LFD et al
Cellular stress defense MAMs function not only as structural platforms for metabolite exchange and signaling but also as key regulatory hubs during oxidative stress, calcium homeostasis disruption, or endoplasmic reticulum protein-folding stress
Regarding its multi-functionality as a nutrient, protein folding, and major component for redox balance due to its involvement in glutathione synthesis, disruption of cysteine homeostasis appears to be promising strategy for induction of cancer cell death
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