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The functions of the BBB and BCB include: protection of the brain from pathogens and toxic metabolites, the separation of the brain and periphery neurotransmitter pools, intake of essential nutrients and discharge of metabolites, and maintaining the immune privilege of the brain, where the immune activity is mainly accomplished by internal microglia rather than, e.g., bone marrow or thymus-derived immune cells (Galea et al., 2007
& Fragoulis, G
You may know free radicals for their role in causing cell damage leading to disease like Alzheimers and cancer
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