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The study was conducted by Dr Marcel Muskiet of Leiden University Medical Center in the Netherlands, Professor David Cherney of the University Health Network and the University of Toronto in Canada and colleagues
PMCID: PMC11932899
2025 Jan;18(1):e70083
Based on our data, we propose that T3 has a regulatory role in insulin-controlled glucose metabolism, and T3 exerts this function by increasing non-12-OH FXR-antagonistic BA levels via downregulating the expression of CYP8B1, which potentiates GLP-1 production via suppressing the intestinal FXR signaling
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