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The FDA has approved two agents specifically for chronic weight management in adults without diabetes: semaglutide 2.4 mg weekly subcutaneous injection (Wegovy, approved June 4, 2021) FDA approval NDA 215256 and tirzepatide 2.5 to 15 mg weekly subcutaneous injection (Zepbound, approved November 8, 2023)
Notably, the diversification of gut microbiota resulting from metformin treatment was observed following oral administration in mice, a phenomenon not replicated with intraperitoneal injection (Broadfield et al., 2022)
The Pen will prevent you from dialing a full dose after you have given yourself 4 weekly doses
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