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Receptor mediated effects of advanced glycation end products (AGEs) on innate and adaptative immunity: relevance for food allergy
BPC-157 primarily engages VEGFR2 signalling cascades while modulating nitric oxide synthase pathways, whereas TB-500 functions through actin-binding mechanisms and integrin receptor modulation
64,65 Tumors may also evade immune surveillance by downregulating tumor-associated antigens (TAAs), selecting for neoantigen-depleted clones, or upregulating alternative inhibitory checkpoints, as observed in EGFR-mutant non-small cell lung cancer (NSCLC) following targeted therapy
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