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Diabetes 54 , 10561063 (2005)
Once the samples reached confluency the cells were subcultured and all tendon fibroblasts between passages 2 and 4 that had a proper growth rate and normal fibroblast shape were used in the experimentation process
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The aggressive titration tail in the 12 mg arm of the Phase 2 trial was strongly associated with higher rates of transient gastrointestinal adverse events, which is why researchers generally favor slower escalation when tolerability is prioritized
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