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One study showed that adverse gastrointestinal effects like nausea and diarrhea were more frequently reported with the 15 mg dose of tirzepatide (49%) versus the 5 mg dose (39%)

Further studies are required to better understand how GGT1, other GGT family members and uncharacterized proteins with GGT activity contribute to extracellular GSH catabolism

Journal of the American Heart Association, 14(5), e041369

By simultaneously activating GLP-1, GIP, and glucagon receptors, it allows researchers to investigate receptor cross-talk, intracellular cascades, and their role in glucose regulation, lipid metabolism, and energy homeostasis