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Deletion of the key catalytic enzyme methylthioadenosine phosphorylase (MTAP) gene is associated with the sensitivity of GSK3368715, 331 and a current phase II clinical study of GSK3368715 in breast cancer has been enrolled (NCT04676516) (Table 1)
The results have been disappointing
[10] The authors of that study note that "berberine exhibited an identical effect in the regulation of glucose metabolism" (as measured on HbA1c and blood glucose levels when fasted and after eating), it even regulated lipid metabolism more than metformin
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