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2017 NNMT knockdown in adipocytes was associated with improved markers of insulin sensitivity and glucose uptake in preclinical in vitro models, linking NNMT to metabolic homeostasis
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In addition to viral replication, these proteins can trigger responses and induce cytotoxic and pro-inflammatory effects in neurons, dendritic cells (DCs), microglia, and macrophages, and astrocyte across the CNS, thereby contributing to the development of NeuroHIV [35,36,37]
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