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NAD+ fuels seven sirtuin proteins, with SIRT1 and SIRT3 playing the most active roles in metabolic regulation
GPX4 is a crucial selenoprotein that converts toxic lipid hydroperoxides (L-OOH) on the cytoplasmic membrane to non-toxic lipid alcohol (L-OH) by utilizing GSH, thus preventing the accumulation of lipid peroxidation to protect cells from ferroptosis (191)
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