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CrossRef Lower core body temperature and greater body fat are components of a human thrifty phenotype M Reinhardt, M Schlgl, S Bonfiglio, S B Votruba, J Krakoff, M S Thearle International Journal of Obesity.2016
[26] Improved metabolic health reduces systemic inflammation, enhances endothelial function, and may restore more favorable hormonal profiles
The accelerated approval is based on part 1 of the ESSENCE trial, in which Wegovy demonstrated a statistically significant and superior improvement in liver fibrosis with no worsening of steatohepatitis, as well as resolution of steatohepatitis with no worsening of liver fibrosis compared to placebo
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