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The FDA has not weighed in on this question yet
This is all part of their pre-qualification process, but you need to meet BMI standards
However, hepatic concentrations of AQ and DEAQ are likely higher as AQ strongly accumulates in the liver ( in vivo may be lower, exposure continues for a prolonged period as the half-life of DEAQ is 10 to 12 days (Krishna and White, 1996
Community Clinic Observations Patient Tolerability Protocol: 15 patients escalated from 0.25 mg to 0.5 mg Observations: ~80 % remained on therapy at 12 weeks versus ~60 % retention in historical full-dose records
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