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They develop gradually over time and may include: Hair loss Premature hair graying Mouth ulcers Breathlessness Pale yellow skin Disturbed vision Numbness, tingling, or pricking in the hands, feet, or legs Difficulty walking and moving around Irritability Depression Poor memory and low cognition Muscle weakness Fatigue (2) Miriam Diaz-Gilbert, a blogger, had a debilitating encounter with vitamin B12 deficiency