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The proportion of participants who prematurely discontinued the trial product because of AEs in both the overall population and the Chinese subpopulation was higher in the oral semaglutide 14 mg arm (9.7% and 11.1%, respectively) than in the oral semaglutide 3 mg (4.7% and 5.9%), oral semaglutide 7 mg (4.5% and 5.6%) and sitagliptin 100 mg (1.7% and 2.2%) arms, with gastrointestinal AEs being the most common reason for discontinuation across all treatment groups

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Additionally, obesity is associated with insulin resistance, chronic inflammation, and hypothalamic-pituitary-gonadal axis dysfunction, all of which can suppress testosterone production