It can restore cell viability, decrease ROS and lipid peroxidation, and minimise dopaminergic neuronal loss and motor deficits ( Berberine, an isoquinoline alkaloid from Berberis spp., has demonstrated promising antioxidant activity via promoting heme oxygenase-1 (HO-1) expression, activating Nrf2/AMPK/SIRT1 signaling, inhibiting the NLRP3 inflammasome, balancing glutathione levels, and regulating mitochondrial redox processes ( Phlorizin, found in M
Another potential question that clinical trials will need to assess is whether GLP-1 drugs are actually safe to take for people without obesity or diabetes, as the weight loss these drugs induce could be a damaging side effect
Berberine: Berberine primarily acts by activating AMPK (adenosine monophosphate-activated protein kinase), an enzyme involved in cellular energy regulation
This recycling ability is particularly crucial for the gut, where oxidative stress levels are high due to constant exposure to food, bacteria, and toxins