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The figure below is a visual depiction of the importance of L cells

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Signs and Symptoms Signs of problems in the sigmoid colon, such as diverticulitis, may include fever, pain in the left lower quadrant (of the abdomen), nausea, vomiting, and changes in bowel habit (often constipation), says Daniel Motola, MD, PhD, a gastroenterologist and hepatologist with Optum Medical Care in Mount Kisco, New York

In people with T2DM, the GIP response is enhanced [11], whereas the GLP-1 response is reduced compared to healthy people [12]