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Moreover IR in PCOS was shown to destroy the effect of gonadotropins, enhance the sensitivity of follicular membrane cells to the luteinizing hormone, and increase the expression of P450c17 and 3-hydroxysteroid dehydrogenase type 2, leading to increased production of androgen (152)
doi: 10.2337/db14-1577 44 ChoiEYangJJiGEParkMSSeongYOhSWet al
otherwise, stomach acid and enzymes will break it down before it can be absorbed
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