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Cycle Guidelines Approach Standard Duration 8-12 weeks Off Period 4-8 weeks Best For General research context Approach Extended Duration 12-16 weeks Off Period 4-8 weeks Best For Longer observation windows Time off is commonly used to limit receptor desensitization
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1,2 The washout period before trying to conceive differs between the two medications, because they clear from the body at different rates: Mounjaro: stop at least 1 month before trying to conceive 2 Wegovy: stop at least 2 months before trying to conceive 1 If you become pregnant while on the medication, stop and contact your prescriber
1 2 G Protein Pathways - Part C, Effector Mechanisms
