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Still, the human body is generally efficient at excreting excess amounts of water-soluble vitamins like B12, so the risk of toxicity is low
Regulatory note: Neither peptide is FDA-approved
Published clinical evidence includes a Phase 1b multiple-ascending-dose trial reported by Enebo and colleagues (Lancet, 2021) and a Phase 2 trial in type 2 diabetes reported by Frias and colleagues (Lancet, 2023), both studying cagrilintide together with semaglutide
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