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Other important risk factors include advanced age (particularly over 65 years), where counter-regulatory hormone responses may be blunted and hypoglycemia awareness reduced
Sex of the animal models To the best of our knowledge, the occurrence of osteosarcoma is not related to the sex of the patient
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Although previous ex vivo studies employing NCI-H716 cells (a human L cell line) [35] or human ileal and colonic tissues [14] were indicative of a direct effect of metformin in stimulating GLP-1 release, clinical evidence suggests that the augmentation of postprandial GLP-1 secretion by metformin is largely indirect
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