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A balanced microbiome appears to be essential for healthy brain function, while microbial perturbations can contribute to cognitive deficits, mood disturbances, and neuroinflammation (Sorboni et al., 2022)
Complementary evidence from national registry analyses shows that obesity frequently precedes the onset of a wide spectrum of psychiatric disorders [4], while Mendelian randomization studies provide converging support for a causal pathway from higher BMI to depression [18]
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