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Studies have shown that GLP-1 receptor agonists like semaglutide can reduce liver fat content and improve liver inflammation and fibrosis, potentially offering a therapeutic option for patients with NAFLD
In select cases particularly patients with: Obesity High insulin resistance Very high total daily insulin requirements endocrinologists may consider off-label use with: Continuous glucose monitoring Routine ketone monitoring Strict sick-day protocols Close specialist follow-up But this is not standard therapy
Long-term safety: Since Survodutide is still in clinical trials, long-term effects on cardiovascular outcomes and cancer risk remain under investigation
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