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Research from the STEP 1 extension trial shows that approximately two-thirds of weight lost is regained within one year of discontinuation
Weight gain can be influenced by many factors, including diet, inactivity, medications, sleep problems, hormonal conditions, and mental health
That trial measured hormone levels rather than body composition, so downstream effects on fat and lean mass are not established by it
GLP-1 receptors undergo tachyphylaxis, a reduction in response with sustained stimulation
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