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This modification enhances NNTs affinity for its substrate NADP+, promoting NADPH synthesis, maintaining ironsulfur cluster homeostasis, lowering intracellular ferrous iron levels and lipid peroxidation, and thereby protecting tumor cells from ferroptosis (118)

Recruited originally to help improve laundry detergent enzymes to make clothes look brighter, Knudsen soon got drawn into a small team set up in 1990 by Ole Kirk, an organic chemist and physician, to discover new peptide candidates to treat type 2 diabetes (Molteni, Chen