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If you experience significant side effects at any dose, you can remain at that dose for 6-8 weeks before escalating, or temporarily step back to the previous dose

Therefore, this combination therapy, often described as pairing a liver-directed therapy (resmetirom) with a systemic metabolic agent (semaglutide), represents a promising, potentially more effective or optimal therapeutic approach than monotherapy in individuals with/without type 2 diabetes who have coexisting MASH [67,68,69]

Some patients find relief from warm baths before bedtime

In some cases, GLP-1 medications can actually help to accelerate skin repair by reducing inflammatory signals